Predictors of critical COVID-19 in an Iranian population: Age and disabilities play a special role
Author(s):
, , , , , , , ,Source: Medical Journal of the Islamic Republic of Iran
Publisher:
Iran University of Medical Sciences
Date
: 2021
Abstract: Background: Ever since coronavirus disease 2019 (COVID-19) has emerged as a global public health problem, risk factors for severe disease have been reported in studies from Western countries. However, apart from studies of Chinese origin, few reports are available on COVID-19 severity among the Asian population. This study investigates potential risk factors for development of critical COVID-19 in an Iranian population. Methods: In this retrospective cohort study, we included all adults with COVID-19 from 2 tertiary centers in Iran who had been diagnosed between February 20 and April 1, 2020, in either inpatient or outpatient settings. “Critical COVID-19” was proposed when a hospitalized patient was scheduled for admission to intensive care unit, assisted by mechanical ventilation, or pronounced dead. We used univariable and multivariable logistic and linear regression models to explore the potential risk factors associated with critical COVID-19, admission to hospital, and length of hospital stay. Results: Of the 590 recruited patients, 427 (72.4%) were hospitalized, 186 (31.5%) had critical COVID-19, and 107 (18.2%) died. In the multivariable regression analysis, age >60 years and physical/mental disabilities were associated with critical COVID-19 (odds ratio (OR), 2.33 and 7.03; 95% CI, 1.51-3.60 and 2.88-17.13, respectively); and history of renal, heart, or liver failure was associated with both COVID-19 hospitalization (OR, 4.13; 95% CI 1.91-8.95; p<0.001) and length of hospital stay (Beta 1.90; 95% CI, 0.763.04; p=0.001). Conclusion: Age >60 years and physical/mental disabilities can predict development of critical COVID-19 in the Iranian population. Also, the presence of renal, heart, or liver failure might predict both COVID-19 hospitalization and length of hospital stay. © 2021 Iran University of Medical Sciences. All Rights Reserved.
DOI: 10.34171/mjiri.35.94
Keyword(s): Age,COVID-19,Disability,Iran,Prognosis,Risk Factor
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contributor author | Bidari A. | |
contributor author | Hassanzadeh M. | |
contributor author | Naderkhani M. | |
contributor author | Mesgarha M.G. | |
contributor author | Mohammad A.P. | |
contributor author | Azadeh A. | |
contributor author | Hossein H. | |
contributor author | Zarei E. | |
contributor author | Khodadost M. | |
date accessioned | 2021-09-21T04:45:11Z | |
date available | 2021-09-21T04:45:11Z | |
date issued | 2021 | |
identifier uri | https://vlib.kmu.ac.ir/kmu/handle/kmu/1033878 | |
description abstract | Background: Ever since coronavirus disease 2019 (COVID-19) has emerged as a global public health problem, risk factors for severe disease have been reported in studies from Western countries. However, apart from studies of Chinese origin, few reports are available on COVID-19 severity among the Asian population. This study investigates potential risk factors for development of critical COVID-19 in an Iranian population. Methods: In this retrospective cohort study, we included all adults with COVID-19 from 2 tertiary centers in Iran who had been diagnosed between February 20 and April 1, 2020, in either inpatient or outpatient settings. “Critical COVID-19” was proposed when a hospitalized patient was scheduled for admission to intensive care unit, assisted by mechanical ventilation, or pronounced dead. We used univariable and multivariable logistic and linear regression models to explore the potential risk factors associated with critical COVID-19, admission to hospital, and length of hospital stay. Results: Of the 590 recruited patients, 427 (72.4%) were hospitalized, 186 (31.5%) had critical COVID-19, and 107 (18.2%) died. In the multivariable regression analysis, age >60 years and physical/mental disabilities were associated with critical COVID-19 (odds ratio (OR), 2.33 and 7.03; 95% CI, 1.51-3.60 and 2.88-17.13, respectively); and history of renal, heart, or liver failure was associated with both COVID-19 hospitalization (OR, 4.13; 95% CI 1.91-8.95; p<0.001) and length of hospital stay (Beta 1.90; 95% CI, 0.763.04; p=0.001). Conclusion: Age >60 years and physical/mental disabilities can predict development of critical COVID-19 in the Iranian population. Also, the presence of renal, heart, or liver failure might predict both COVID-19 hospitalization and length of hospital stay. © 2021 Iran University of Medical Sciences. All Rights Reserved. | |
language | English | |
publisher | Iran University of Medical Sciences | |
subject other | COVID-19 | |
title | Predictors of critical COVID-19 in an Iranian population: Age and disabilities play a special role | |
type | Article | |
contenttype | Metadata Only | |
subject keywords | Age | |
subject keywords | COVID-19 | |
subject keywords | Disability | |
subject keywords | Iran | |
subject keywords | Prognosis | |
subject keywords | Risk Factor | |
journal title | Medical Journal of the Islamic Republic of Iran | |
identifier doi | 10.34171/mjiri.35.94 | |
identifier link | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107446919&doi=10.34171%2fmjiri.35.94&partnerID=40&md5=686cc4adfc12eb05bd7ef6469c294314 | |
address author | Bidari, A., Department of Rheumatology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Hassanzadeh, M., Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Naderkhani, M., Emergency Medicine Management Research Center, Iran University of Medical Sciences, Tehran, Iran; Mesgarha, M.G., School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Mohammad, A.P., Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Azadeh, A., School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Hossein, H., Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Zarei, E., Ali-Asghar Children Hospital, Department of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Khodadost, M., Department of Epidemiology, School of Public Health, Larestan University of Medical Sciences, Larestan, Iran, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran | |
database | Scopus | |
affiliations | Department of Rheumatology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Emergency Medicine Management Research Center, Iran University of Medical Sciences, Tehran, Iran; School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Ali-Asghar Children Hospital, Department of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Epidemiology, School of Public Health, Larestan University of Medical Sciences, Larestan, Iran; Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran |